While several studies have reported associations between proton-pump inhibitor (PPI) use and dementia, the authors of a new report say they have found no convincing evidence to support the suggestion that PPI use increases dementia risk.
The research directly responds to a 2016 pharmacoepidemiologic analysis conducted using a large German health insurance database, which identified an association between dementia and long-term PPI use.
For this study, published in Gastroenterology , the authors analysed data from 13,864 participants from a large prospective study into risk factors for major chronic diseases for women, who completed testing on cognitive function.
The authors observed a modest association between duration of PPI use and scores for psychomotor speed and attention. After controlling for H2 receptor antagonists (H2RA) use, the magnitude of this score difference was attenuated. Among those who did not regularly use PPIs, duration of H2RA use was associated with poorer cognitive scores, with the strongest association apparent for learning and working memory.
The authors said the data do not support the suggestion that PPI use increases dementia risk. Since the primary hypothesis related to PPI use, the “findings for H2RAs should be interpreted with caution”, the added.