An international collaboration led by scientists at Nagoya University in Japan is proposing that a new category of genetic skin diseases is defined.
In an article published in the Journal of Allergy and Clinical Immunology , the authors point out that among the genetic causes/predisposing factors for inflammatory keratinisation disorders, several factors are associated with auto-inflammatory mechanisms. They are advocating for the novel and unique concept of auto-inflammatory keratinisation diseases (AIKDs).
The authors propose that conditions which meet the following criteria be defined as AIKDs: “First the primary and main inflammation sites are the epidermis and the upper dermis. Second, inflammation in the epidermis and upper dermis leads to hyperkeratosis, which is the main and characteristic phenotype of AIKDs.”
“We have been finding more and more of these auto-inflammatory related skin diseases and it’s time we recognise this as a new category of inflammatory keratinisation disease,” said co-author of the paper, Kazumitsu Sugiura. “A better understanding of the root causes of skin problems is the only way for physicians to help patients manage their conditions and develop more effective treatments.”