New app predicts cardiovascular events in liver transplant patients

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Scientists have created the first liver transplant-specific score to predict cardiac risk in liver transplant patients.

Scientists have developed the first app and score to determine one-year risk of a liver transplant patient dying or being hospitalised for myocardial infarction or other cardiovascular (CV) complication.

Approximately one-third of liver transplant recipients will have a CV complication in the first year after a liver transplant. Until now however, doctors have depended on risk tools developed in non-liver transplant populations to estimate the risk for CV events after orthotopic liver transplantation (OLT).

The new Cardiovascular Risk in Orthotopic Liver Transplantation (CAR-OLT) score was developed using data from a cohort of 1,024 patients, aged 18-75 years, who underwent first OLT in a tertiary care teaching hospital over a 10-year period. Among the cohort, major cardiovascular disease (CVD) complications occurred in 32.1 per cent. The CAR-OLT point-based score was found to be superior to other published risk models for postoperative CVD morbidity and mortality.

Writing in Hepatology , the authors said further external validation of the findings in a larger multicenter clinical trial is needed to assess whether use of the CAR-OLT score for risk stratification and the decision to proceed with more intensive cardiovascular testing or targeted risk factor reduction would be helpful to improve CVD outcomes after OLT.


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