Several recent studies have raised safety questions about the use of proton pump inhibitors (PPIs), suggesting they increase the risk for dementia and Alzheimer’s disease (AD) in people 75 years old or older.
A new study published in the Journal of the American Geriatrics Society may help to quash these concerns, after finding that PPIs were not associated with greater risk for dementia or AD.
Scientists examined data relating to 10,486 people aged 50 years or older, with either normal brain function or mild cognitive impairment. They found there was actually a decreased risk of cognitive decline among people who used PPIs regularly or occasionally, after adjusting for potential confounders.
In terms of adjusted survival curves of cognitive decline to mild cognitive impairment (MCI) or dementia, always PPI users had the highest survival rate, with intermittent users in the middle and never PPI users in the lowest group. A higher percentage of people who took PPIs regularly or occasionally also took a higher percentage of anticholinergic medications, which have also been linked to cognitive impairment.
The authors said prospective studies are needed to confirm these results to guide empirically-based clinical treatment recommendations.