Previous studies have suggested that low vitamin D levels are associated with increased risk for asthma, atopic dermatitis and elevated levels of IgE. However, a new study published in PLOS Medicine , suggests vitamin D supplementation is unlikely to reduce the risk of allergic conditions.
The analysis of 100,000 individuals of European descent found no statistically significant difference between rates of asthma, atopic dermatitis, or IgE levels in people with or without any of the four genetic changes associated with lower levels of 25-hydroxyvitamin D.
“Our findings suggest that previous associations between low vitamin D and atopic disease could be due to spurious associations with other factors,” said Dr. Despoina Manousaki, the lead author. “Efforts to increase vitamin D levels will probably not result in decreased risk of adult and paediatric asthma, atopic dermatitis, or elevated IgE levels.”
The results do not however exclude an association between the outcomes and levels of 1,25-dihydroxyvitamin D, and the authors say more work will be needed to determine if the results hold true in non-European populations and in people with frank vitamin D deficiency.