Can aspirin prevent miscarriage?

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The ability of aspirin to sustain pregnancy was linked to levels of C-reactive protein.

Findings from a new analysis suggest taking daily low-dose aspirin (LDA) may increase clinical pregnancy and live birth rates in women attempting conception who have elevated high-sensitivity C-reactive protein (hsCRP) and prior pregnancy loss.

In making the findings, researchers examined data originally obtained from the Effects of Aspirin in Gestation and Reproduction  (EAGeR) trial which sought to determine if LDA could prevent subsequent pregnancy loss among women who had one or two prior losses.

For this study, women were classified into three groups: those with low CRP, mid CRP and high CRP. Each received either daily LDA or a placebo.

The authors found those with high CRP in the placebo group had the lowest rate of live births at 44 per cent, while those taking daily aspirin had a live-birth rate of 59 per cent. Aspirin also appeared to reduce CRP levels in the high CRP group. There were no significant differences in birth rates between those receiving aspirin or placebo in the low and mid CRP groups.

The authors said more research is needed to confirm the findings.


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